Description
Clariflow®-B biological retentive filter cartridges are designed to deliver sterilizing-grade filtration for pharmaceutical and biopharmaceutical applications. Engineered with a 0.2 µm mirrored-anisotropic polyethersulfone (PES) membrane, Clariflow®-B ensures consistent microbial retention, high flow rates, and reliable performance for critical process fluids.
These filters are optimized for end-product purity, stability, and efficiency when filtering water, buffers, culture media, and biologics.
What is Clariflow®-B?
Clariflow®-B is a biological-grade, sterilizing filter cartridge featuring a single-layer PES membrane with low protein binding, high chemical compatibility, and full bacterial retention (LRV > 7). The design supports demanding sterile filtration processes in regulated environments such as biotech manufacturing and pharmaceutical production.
Each cartridge is:
- Manufactured with polypropylene components
- Constructed with an inherently hydrophilic PES membrane
- Free from added surfactants or wetting agents
- Designed for consistent and reproducible filtration performance
Key Features & Benefits
- Sterilizing Grade Filtration (0.2 µm PES Membrane)
Validated for bacterial retention using Brevundimonas diminuta in accordance with ASTM F838 standards. - High Flow Rate Performance
Optimized membrane structure supports efficient throughput and reduced processing time. - Low Protein Binding
Minimizes product loss and preserves valuable biologics and proteins. - Biologically Inert Construction
Ensures chemical compatibility across a wide range of solutions and buffers. - Full Bacterial Retention (LRV > 7)
Provides reliable sterility assurance for critical applications. - Integrity Testing Correlation
Non-destructive integrity testing methods correlate with bacterial retention for validation and quality assurance. - PFAS-Free Design
Constructed using polypropylene components and PES filtration media without PFAS materials. - Cleanroom Manufactured & Pre-Flushed
Each cartridge is produced in a controlled cleanroom environment, pre-flushed with deionized water, and 100% integrity tested prior to shipment.
Applications
Clariflow®-B sterilizing grade filter cartridges are ideal for a wide range of biopharmaceutical and pharmaceutical filtration applications, including:
- Pharmaceutical Products
- Parenteral Solutions
- Ophthalmic Solutions
- Diagnostic Reagents
- Biological Growth Media
- Concentrated Proteins
- Vaccines
- Downstream Purification Bioproducts
- Chromatography Column Buffers
- Blood and Plasma Fractionation
- Water for Injection (WFI)
Why Choose Clariflow®-B Filters?
Clariflow®-B cartridges are engineered to meet the stringent requirements of modern bioprocessing, offering a balance of sterility assurance, performance, and regulatory compliance. Their validated bacterial retention, low extractables, and hydrophilic PES membrane make them a dependable choice for critical sterilizing filtration steps.