Description
Clariflow®-P pharmaceutical filter cartridges are designed for sterilizing-grade filtration in biopharmaceutical and pharmaceutical applications, ensuring reliable microorganism removal and end-product sterility.
Built with a dual-layer mirrored-anisotropic polyethersulfone (PES) membrane (0.2 µm), Clariflow®-P cartridges deliver consistent bacterial retention (LRV >7) and high-performance filtration for critical processes.
Manufactured using all-polypropylene components and an inherently hydrophilic PES membrane, these cartridges contain no surfactants or wetting agents, helping preserve product purity and integrity.
Each filter is:
- Produced in a controlled cleanroom environment
- Pre-flushed with deionized water
- 100% integrity tested prior to shipment
Why Choose Clariflow P Filter Cartridges?
Clariflow®-P filters are engineered for high-purity, high-reliability applications, offering:
- Sterilizing-grade filtration performance
- Validated bacterial retention (ASTM F838)
- Low protein binding for maximum yield
- Broad chemical compatibility
- PFAS-free construction
- Compliance with USP <665> extractables & leachables standards
Key Features & Benefits
Sterilizing-Grade Bacterial Retention
- Validated using ASTM F838 liquid bacterial challenge with Brevundimonas diminuta
- Achieves >7 log reduction value (LRV)
- Ensures regulatory-compliant sterile filtration
Dual-Layer 0.2 µm PES Membrane
- Mirrored-anisotropic membrane structure
- Provides redundant bacterial retention within a single cartridge
- Enhances process safety and consistency
Integrity Test Correlation
- Fully correlated to bacterial retention performance
- Enables non-destructive integrity testing
- Confirms filter performance before and after use
Low Protein Binding & Biologically Inert
- Maximizes product recovery and yield
- Ideal for protein-sensitive and high-value biologics
- Minimizes risk of adsorption and loss
PFAS-Free Construction
- Manufactured with:
- Polypropylene hardware
- PES membrane media
- Supports regulatory and environmental compliance initiatives
Extractables & Leachables Tested
- Tested per USP <665> guidelines (moderate-risk applications)
- Ensures low risk of contamination in critical processes
Applications
Clariflow®-P cartridges are ideal for sterilizing-grade filtration of critical fluids, including:
- Pharmaceutical products
- Parenteral solutions
- Ophthalmic solutions
- Diagnostic reagents
- Biological growth media
- Vaccines
- Concentrated proteins
- Chromatography buffers
- Downstream bioprocessing fluids
- Blood and plasma fractionation
- Water for Injection (WFI)
Technical Advantages for Biopharma Filtration
Clariflow® -P PES filters are optimized for modern biopharmaceutical manufacturing, supporting:
- High-throughput sterile filtration
- Consistent microbial retention
- Reduced risk of batch contamination
- Improved process efficiency
- Compatibility with sensitive biologics