MicroMedia L Series: Depth Filter Sheets

Formulated using high purity cellulose to reduce the occurrence of false positives caused by 1,3 beta D glucans in cellulose pulp.

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Micro-Media L Series Depth Filter Media, is specifically designed for use in applications where proteins are present, such as blood fractionation and recombinant DNA derived products. These particular types of applications demand specific controls on pyrogens and extractables. Physical attributes, unique to such applications can lower the surface tension of the media and cause them to release extractables, which can cause problems with the LAL testing used both in process and as a final release. These extractables can cause “false positives” by reacting with a Factor G in the LAL reagent and cellulose components.

A particular source of extractables is 1,3 ß D-glucan contamination in the cellulose. Cellulose is a major component of depth filter products. The level of reactivity depends upon the amount of 1,3 ß D-glucans released during manufacturing of the filter media and the amount of Factor G present in the LAL reagent, which varies by

Utilizing a unique process, ErtelAlsop minimizes 1,3 ß D-glucan levels in cellulose pulp prior to manufacturing the filter media. This minimizes the effects of 1,3 ß D-glucans and allows for validation of the LAL test on the product.

Additional information




Cellulose (High Purity), DE (Diatomaceous Earth)

Retention Ratings



• Extremely low 1,3 B D-glucan content
• Lower frequency of false positive LAL tests

• Blood Fractions
• Recombinant DNA Derived Products
• Sera
• Cell Culture Media
• Active Pharmaceutical Ingredients
• Large Volume Parenterals
• Small Volume Parenterals